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Newborns with significant congenital deformities often have complex, immediate needs that require constant monitoring and access to specialized equipment and multidisciplinary care. The Neonatal Intensive Care Unit is designed to provide this level of support, including continuous vital-sign monitoring, respiratory support or ventilatory care if needed, thermoregulation, precise nutrition, and IV therapies, along with rapid involvement of neonatologists, pediatric surgeons, and allied health professionals. This setting also enables prompt evaluation for associated conditions and planning for any required surgical or medical interventions. Other settings, such as a school clinic, outpatient therapy, or home care, lack the necessary infrastructure and round-the-clock monitoring to safely manage high-risk newborns with major congenital deformities.